生秀梅，教授，碩士生導師，醫學生物化學教研室主任，主要從事病原菌緻病分子機制及腫瘤發生發展機制的研究。郵箱：shengxiumei@ujs.edu.cn

【學習工作經曆】

2017.05-至今，江蘇大學，醫學院基礎醫學系，教授

2013.05-2014.05，美國德克薩斯大學MD安德森癌症中心，訪問副教授

2011.08-2017.04，江蘇大學，醫學院基礎醫學系，副教授

2005.08-2011.07，江蘇大學，醫學技術學院，講師

2003.09-2005.06，華中師範大學研究生學報，兼職編輯

1999.08-2005.07，江蘇大學，醫學院，助教

2006.09-2009.12，江蘇大學，博士

2002.09-2005.07，華中師範大學，碩士

1995.09-1999.07，華中師範大學，學士

【教改科研項目】

1．江蘇省自然科學基金面上項目，BK20191429，GLIPR1抑制肺癌生長的分子機制及靶向治療研究，在研，主持；

2.國家博士後基金面上項目，2015M571702，Mig-14參與傷寒沙門菌緻病機制研究，結題，主持；

3．國家青年自然科學基金項目，31000046、Mig-14參與傷寒沙門菌耐多粘菌素B機制研究，已結題，主持；

4．江蘇大學高級人才啟動基金項目，11JD063、Mig-14參與傷寒沙門菌耐藥機制研究，在研，主持；

5．江蘇省教育廳項目，08KJD310012、、高滲應激下PhoP與OmpR交叉調節傷寒沙門菌基因表達，已結題，主持。

【代表性論文】

1.Wang JJ, Li ZY, Yin FF, Zhang R, Zhang Y, Wang ZX*,Sheng XM*, Glioma pathogenesis-related protein 1 performs dual functions in tumor cells, Cancer gene therapy, 2021, online ahead of print. doi: 10.1038/s41417-021-00321-9.

2.Altayyar MA,Sheng XM, Wang ZX. WD repeat domain 77 protein regulates translation of E2F1 and E2F3 mRNA. Mol. Cell Biol. 2020, 40(24): e00302-20.

3.Lu W, Cao FH, Wang SJ,Sheng XM*, Ma J*. LncRNAs: The Regulator of Glucolipid Metabolism in Tumor Cells.Front. Oncol. 9: 1099. doi: 10.3389/fonc.2019.01099.

4.Sheng XM, Wang WW, Chen L, Zhang H, Zhang Y, Xu SG, Xu HX, Huang XX. Mig-14 may contribute toSalmonella entericaserovar Typhi resistance to polymyxin B by decreasing the permeability of the outer-membrane and promoting the formation of biofilm. International Journal of Medical Microbiology, 2019, 309(2):143～150. (SCI收錄)

5.Sheng XM, Bowen N, Wang ZX. GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Mol Cancer. 2016, 15(1):25. (SCI收錄)

6.Sheng XM, Wang ZX. Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation. BMC cancer. 2016, 16: 567.

7.Sheng XM, Zhang H, XiaQF, et al. Mig-14 plays an important role in influencing gene expression of salmonella enterica serovar Typhi, which contributes to cell invasion under hyperosmotic conditions. Research in Microbiology. 2013, 903～912. (SCI收錄)

8.Sheng XM, Xu SG, Lu RY, et al. Design of a comprehensive biochemistry and molecular biology experiment: Phase variation caused by recombinational regulation of bacterial gene expression. Biochemistry and molecular biology education. 2014, 224～229. (SCI收錄)

9.Sheng XM, Huang XX, Mao LX, et al. Preparation of salmonella enteric servor Typhi genomic DNA microarrays for gene expression profiling analysis. Prog. Biochem. Biophy, 2009, 36(2): 206～212(SCI收錄)

10.Sheng XM, Huang XX, Li JH, et al. Regulation of sulphur assimilation pathways insalmonella enterica serovar Typhi upon up-shift high osmotic treatment: the role of UhpA revealed through transcriptome profiling. Curr Microbiol. 2009, 59: 628～635. (SCI收錄)

【獲獎與專利】

生秀梅，黃新祥，徐順高等.傷寒沙門菌DNA芯片轉錄表達譜用基因組特異引物. 200910031165.4已授權